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Amanita Testing

Amanita, a genus of mushrooms, are well-known for their bioactive compounds, many of which belong to the isoxazole class. Isoxazoles, characterized by a five-membered ring containing an oxygen atom and a nitrogen atom, include prominent compounds like Muscimol and Ibotenic Acid. Understanding these compounds' quantities in Amanita species is crucial due to their significant pharmacological effects, making them subjects of interest for both safety evaluation and therapeutic research.

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Compounds We Quantify


Muscimol is a naturally occurring psychoactive compound primarily found in the Amanita muscaria (fly agaric) and a few other species of Amanita mushrooms. It acts as a potent agonist at certain subtypes of the GABA-A receptors, leading to a range of effects from mild euphoria and dream-like states to hallucinations.  Quantifying muscimol is crucial for assessing the potency and safety of products derived from these mushrooms.

Ibotenic Acid

Ibotenic Acid is another psychoactive compound present in several Amanita species. It acts as a powerful agonist at both the NMDA and certain metabotropic glutamate receptors. Notably, Ibotenic Acid can decarboxylate into muscimol, which contributes to the psychoactive effects of the mushrooms. Ibotenic acid also exhibits neurotoxic properties, leading to brain lesions in high doses, which underpins the importance of its quantification in Amanita products.


Alpha-Amanitin is a highly toxic compound found predominantly in Amanita phalloides (the death cap) and a few other Amanita species. It is one of the amatoxins that works by inhibiting RNA polymerase II, an essential enzyme for mRNA synthesis, leading to cell death. Ingesting Amanita mushrooms with this toxin can cause severe liver and kidney damage and potentially result in death, hence the importance of testing for Alpha-Amanitin to ensure the safety of mushroom-derived products.

Why Test With Us?

     At Tryptomics, we understand the vital importance of ensuring the safety and efficacy of your products. When it comes to testing Amanita, our expert team leverages years of experience and state-of-the-art technology to accurately quantify key compounds like Muscimol, Ibotenic Acid, and Alpha-Amanitin, regardless of whether the samples are from raw fruit bodies, concentrates, or edible products.

     Our extensive Quality Control (QC) procedures are at the heart of our methodology. Through rigorous internal standards and calibration methods, we guarantee both accuracy and precision in our results. We constantly validate and refine our testing procedures, working diligently to eliminate potential sources of error. As a result, you can trust us to provide dependable data that accurately reflects the profile of your product.

     Choosing Tryptomics for your Amanita testing needs means choosing reliability and peace of mind. With our comprehensive testing services, you can ensure your products are safe, effective, and meet the highest standards of quality. Together, we can support the responsible development and use of Amanita-derived products.

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